Awametox Ab

AWAMETOX (http://awametox.com/) has developed SpotRM, the leading expert tool for decision support to avoid test substances with potential reactive metabolite problems. Input structures that contain substructures, which can undergo bioactivation to form reactive intermediates are readily identified by matching with a set of carefully selected structural alerts (SA). The core of our selection of SAs is reviewed in a 2018 Perspective paper: A. Claesson & A. Minidis, Chem. Res. Toxicol. • Potential hazards in input structures are highlighted on the structure and the SA matches are listed. • The SAs are hardwired to drug examples, whose mechanisms of activation are described in summaries. • The concept provides unprecedented, easy access to the most relevant information on structural alerts and reported evidence of their involvement in adverse events. SpotRM is a web-based tool (at spotrm.com) and access is gained via a license fee.