G23 Instruments

G23 Instruments design and manufacture precision engineered, minimal drift, low noise microelectrode holders for electrophysiology research groups around the world. We work closely with active research staff within the Department of Neuroscience, Physiology & Pharmacology at University College London and other international institutes. We market microelectrode holders for Axon Instruments’ head-stages, all HEKA patch clamp amplifiers and most NPI and Dagan electronic amplifiers. Over the years our electrode holders have been recommended for low drift long term recording and stability by both Axon (prior to their takeover by Molecular Devices) and Burleigh Instruments. Our current designs are by Dave Osborne, who was the prototype engineer in the UCL Pharmacology department workshop. They have been developed with input and collaboration from active researchers and we are able to customise our microelectrode holders to suit particular requirements. The design of our electrode holders greatly reduces the chance of pipette movement during patch clamp recording, which is undesirable but often occurs during changes in pipette pressure. It does this by supporting the electrode glass at two points. Our holders are precision engineered (rather than moulded) for discrete sizes of pipette glass and we can ensure less drift during an experiment than those from other manufacturers whose holders can accommodate multiple sizes. Manufactured from low noise polycarbonate our holders add less electrical background noise during recording than those from some manufacturers who use metallized components.