Pelican Expression Technology

Pelican Expression Technology® The Pelican Expression Technology® platform is a robust, cost-effective, and scalable platform for recombinant protein production. This unique Pseudomonas fluorescens–based cell expression system has been designed for complex protein production that cannot be achieved using traditional systems, whether due to low titer, poor quality, or commercial suitability. Partners seek the platform as it can contribute significant value to biopharmaceutical development programs by shortening development timelines and cutting manufacturing costs. The Pelican Expression Technology® platform's versatility has been demonstrated by the successful, high-yield production of enzymes, peptides, antigens, antibody derivatives, and other engineered non-natural proteins. As the demand for large, structurally-complex biologics continues to grow, Pelican’s comprehensive, broadly-available protein production platform is well positioned to meet the associated manufacturing needs. PeliCRM197® The PeliCRM197® carrier protein, produced using Pelican’s state-of-the-art Pseudomonas fluorescens–based Pelican Expression Technology® platform, is the first and only commercially available cGMP compliant CRM197 to be used in a marketed conjugate vaccine. CRM197 is a genetically detoxified version of diphtheria toxin that has been used as a carrier protein in conjugate vaccines for over three decades. Pelican’s PeliCRM197® carrier protein boasts better quality, higher purity, and greater scalability compared to other commercially produced CRM197s.