Pharm-Analyt - Bioanalysis

BIOANALYSIS Assay development, validation and implementation (HPLC-MS/MS, UV and Fluorescence) determining analytes in complex matrices (plasma, urine, tissue) during preclinical, clinical phases and discovery phase. GLP and GMP certified. QUANTIFICATION (in Plasma, Urine, Tissue)- Small Molecules (f.i. 250 fg/mL in plasma)- Peptides (up to 10 kDa)- PEG (Polyethylene glycol)- Polymers like PEI and Polyoxazolines - Polysaccharides IDENTIFICATION Structure Elucidation of Unknown Peaks- Metabolite Profiling - Impurities & Degradation Products - Side & Byproducts INVESTIGATION - Bioanalytical Feasibilities (2-4 days)- Tissue Analysis - Enantioselective Separation in Plasma - Trouble Shooting BIOMARKERS Discovery of Biomarkers in Plasma - Small Molecules - Peptides Several Patents (Orphan Diseases) EQUIPMENT: LTQ Orbitrap XL (Thermo Scientific) HPLC-MS/MS QTRAP 6500 SelexION (AB Sciex) HPLC-MS/MS Xevo TQ-XS (Waters) As well as conventional detectors like ELSD.