Requisite Biomedical, Llc

Pro-healing solutions for vascular interventions Requisite Biomedical is an early stage device company aimed at developing novel coatings for drug-eluting stents and drug-coated balloons. Our device coatings utilize naturally occurring compounds that promote vascular healing responses, so as to improve long-term outcomes for endovascular interventions. Overview: ReQuisite Biomedical was founded in 2009 to develop intravascular medical device coatings containing a combination of the natural compounds found in red wine - resveratrol and quercetin. The two compounds act in synergy to prevent negative responses to angioplasty treatment that cause re-narrowing of the arteries following a clinical intervention. However, unlike the drugs currently used for drug-coated balloon (DCB) and drug-eluting stent (DES) coatings, these compounds have limited toxicity to vascular cells and have been shown to actively promote positive responses of endothelial progenitor cells, key mediators of the healing response. Resveratrol and quercetin target multiple pathways in disease pathogenesis and should provide a superior healing response compared to products currently on the market and in development.