Silicon Kinetics

Silicon Kinetics produces next generation Biomolecular Interaction Analysis equipment using porous silicon consumables. The SKi Pro product line is used for biomolecular interaction analysis studies where protein binding kinetics is studied without labels, and for affinity capture mass-spectrometry. The SKi Pro® allows extremely effective biomolecule interaction analysis to determine on and off rates and resultant KDs. The technique is valuable for study antibody-antigen, protein-peptide, protein-small molecule, nucleic acid and nucleic acid-protein interactions. Some applications that the Ski Pro has been successfully used for are as follows:* Therapeutic antibody / protein / aptamer development: Peptide library screening, KD determination for lead selection and affinity maturation, Epitope mapping, Kinetic characterization of ultra-high affinity binders.* Analytical antibody development * Biomarker: discovery, analytical development, routine measurement * Signal transduction and other basic research including kinetic characterization of protein-protein and protein-DNA interactions, mutant protein characterization, alanine scans etc.* Small molecule drug discovery: secondary screens, lead selection and in depth characterization, chemical genomics * Affinity Kinetics-Mass Spectrometry: ligand/molecular target identification, drug metabolite binding, fragment-based discovery, screening applications.* A leading application of biomolecular interaction analysis technology is the characterization of antibody- antigen interactions. The desired capabilities of such technology include both fast screening of primary clones and in depth characterization of analytical and therapeutic antibodies including ability to measure ultra-high affinity interactions. Silicon Kinetics Inc has headquarters in San Diego, CA.