Trpl, Llc

TRPL,LLC is an R&D company founded in May 2013, which has state of art R&D facility located in NY & NJ. At TRPL, we specialize in advanced formulation and analytical services for transdermal, topical, subcutaneous, and cosmetic drug delivery systems. With extensive experience in preclinical development, we support pharmaceutical and biotech companies with robust, science-driven solutions. Transdermal Drug Delivery We offer comprehensive support in the development and testing of transdermal systems, including: • Preformulation & Formulation o Transdermal formulation strategy and optimization • In Vitro Testing o IVPT: Human cadaver skin permeation studies o IVRT: Synthetic membrane diffusion studies o Franz diffusion cell studies • Matrix Patch Development & Testing o Matrix system design o Cold flow testing o Adhesion and probe tack measurements o Peel adhesion and liner release studies • Gel Formulations o Transdermal gel developme Topical Drug Delivery We develop and evaluate a wide range of topical dosage forms tailored to your product goals: Formulation Expertise o Solutions, gels, emulsions, creams, ointments o Preformulation and stability develop In Vitro Evaluation o IVPT: Human cadaver skin o IVRT: Synthetic membranes Analytical Testing Our lab is equipped to perform precise, validated analytical methods using HPLC: • Assay development • Stability testing Subcutaneous Formulation Development We support early-stage injectable product development with: • Preformulation design • Formulation optimization for subcutaneous administration Iontophoresis Studies We conduct electrical-assisted drug delivery studies including: • Human cadaver skin permeation studies (IVPT) • Synthetic membrane diffusion (IVRT) Formulation & Compatibility Studies • Solubility enhancement strategies • Drug–excipient compatibility studies for optimized formulation stability Cosmetic & OTC Product Development • TEWL (Transepidermal Water Loss) measurement • Hydration level testing