Annabelle Biscans
Director - Oligonucleotides and Targeted Delivery at Astrazeneca
Based in Sweden
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Seniority
Director
Department
Other
Location
Sweden
Industry
Pharmaceutical Manufacturing
Company size
78K
Contact information
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a•••••••@astrazeneca.com
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Background
About Annabelle Biscans
Over the past 10 years, I have acquired a robust expertise in designing and developing novel chemical modalities to improve oligonucleotide therapeutic delivery. Before joining the Oligonucleotide chemistry team at AstraZeneca R&D, I performed a postdoctoral associate at the RNA Therapeutics Institute, USA in Anastasia Khvorova’s lab, one of the pioneers in oligonucleotide therapeutics research. There, I made major contributions to the development of novel chemical platforms for enhancing the delivery and uptake of siRNA therapeutics. I was able to design and identify novel conjugated siRNAs that enable safe, sustainable and robust silencing in various extra-hepatic tissues including muscle, heart, and lung. This crucial discovery allows for the targeting of several new targets for therapeutic intervention and advance the oligonucleotide therapeutics field.
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