David Arnott

Background

About David Arnott

I am currently retired after thirty years of scientific research, most of it in the Protein Sciences branch of Genentech's Research and Early Development organization. I was educated at the University of Delaware in Philosophy (B.A.) and Chemistry (B.S.) and in 1994 I earned a Ph.D. in Chemistry with Donald Hunt at the University of Virginia. My graduate research included mechanisms of peptide collision-induced dissociation and sequencing naturally-processed peptide antigens presented by HIV-infected cells. I did a three year post-doctoral fellowship at Genentech, Inc. in the laboratory of John Stults using the nascent technologies of proteomics to study a model of congestive hear failure. I was appointed Scientist in the Protein Chemistry Department of Genentech in 1997, becoming a member of the primary large molecule mass spectrometry laboratory supporting Genentech Research. Our mission was to use the tools of our trade in basic biochemical research and help translate biochemical knowledge into new medicines. In 2003 I took over management responsibility for that group, and oversaw its growth from four members to a staff of 14 Scientists, Research Associates, and Postdoctoral Fellows. Returning to a primarily scientific role in 2010, I was a Principal Investigator within the Microchemistry, Proteomics, Lipidomics, and Next Generation Sequencing Department. My research interests included epigenetics, cancer immunology, Alzheimer’s disease, protein structural analysis, and biomarkers, pursued though technologies such as low-level protein capture, targeted and quantitative proteomics, and a career-spanning preoccupation with tandem mass spectrometry and de novo protein sequencing. I was author or co-author of over 75 peer-reviewed papers that have been collectively cited almost ten thousand times in other publications. I am also co-inventor on two granted patents, and served on committees of several professional organizations and on the board of directors of one. Also as a reviewer of grants and papers for several organizations and journals. A list of my publications can be found on Research Gate: