Duncan Hannah

Background

About Duncan Hannah

Innovative, committed and experienced medicinal chemist with a passion for drug discovery. Expertise in projects from hit ID to lead optimisation, with a track record of success developing hits against enzyme, kinase, ion channel, transporter and GPCR targets focussed on CNS, metabolism, cardiovascular, urology, oncology, inflammation, allergy and autoimmune diseases. Exemplary problem-solving and data analysis capabilities.Key Skills• Industrial Medicinal Chemistry experienceo Experienced in hit ID, hit-to-lead and lead optimisation small-molecule drug discovery.o Target classes including enzymes, GPCRs, ion channels, kinases and transporters. o Involved in seven projects that delivered one or more clinical/pre-clinical candidates.o Co-author/inventor on 12 papers and 14 patents.• Synthetic Organic Chemistryo Innovative synthetic contribution to 19 medicinal chemistry programmes.o Efficient synthesis of novel compounds, applying conventional and array chemistry.o Milligram to gram scale final compound synthesis to high purity.• Scientific Leadership and Teamworko Led five multidisciplinary project teams, focussed on progression of small-molecule drug discovery projects from hit ID through to lead optimisation. o Takeda chemistry leader on an external research collaboration.o Project leader on UK/Japan lead optimisation project.o Developing and leading scientific project strategy, including medicinal chemistry strategy.o Successful progression to delivery of preclinical candidates to tight timelines.• Data Analysis and Manipulationo Expert data analysis skills with informatics tools (Dotmatics Browser and Vortex, StarDrop and Spotfire) to interrogate large datasets.• Managemento Managed performance of graduate and PhD chemists.o Managed and directed department-wide chemistry at multiple CROs.