Garrett Tolbert

Background

About Garrett Tolbert

Ph.D. chemist trained in synthesis and characterization of small molecules and organometallic systems, with a strong background in mechanistic profiling of metallocofactor reactivities in enzymatic and biomimetic model systems. I currently work as a Method Development and Validation Specialist in a cGMP laboratory producing lipid adjuvants, and excipients. My work involves collaboration with cross-functional teams to provide analytical support in areas including cGMP compliant method development, DoE, event investigations, CAPA implementation, etc. Highly familiar with UHPLC systems coupled to CAD, ELSD, and TOFMS detectors and compendial testing methods including NMR, KF, IC, ICP, TOC, etc.Presentations and Publications:Tolbert, G. T; Wijeratne, G. B."Oxidative Ring Cleavage of N-Acetyl-3-MethylIndole-2,3-Epoxide by a Ferryl Heme: Experimental Evidence for the Proposed Second Step in TDO/IDO-Mediated Tryptophan Dioxygenation." Manuscript in Preparation.Tolbert, G. T; Jayawardana, S. B; Whitt, L. M; Wijeratne, G. B."Proton-Coupled Electron Transfer Reactivity Modulation in Heme Superoxide Complexes via Electronically Divergent Secondary Sphere Interactions." Manuscript in Preparation.Tolbert, G. T; Jayawardana, S. B; Lee, Y; Sun, J; Qu, F; Whitt, L. M; Shafaat, H. S; Wijeratne, G. B."Secondary Sphere Lewis Acid Activated Heme Superoxo Adducts Mimic Crucial Non-Covalent Interactions in IDO/TDO Heme Dioxygenases." Chemistry – A European Journal, 2024. DOI: 10.1002/chem.202402310.Mondal, P; Tolbert, G. T; Wijeratne, G. B."Bio-inspired nitrogen oxide (NOx) interconversion reactivities of synthetic heme Compound-I and Compound-II intermediates." Journal of Inorganic Biochemistry. 2022, 226, Rates of Indole Dioxygenation by a Synthetic Heme Model in the Presence of Lewis Acid Coordination Complexes." Southwest Regional Meeting of the American Chemical Society, Austin, TX. November 2021.(Oral).Awards:NSF EPSCoR, Graduate Research Scholars Program Fellowship Recipient 2021-2024UAB Chemistry Dept, Award for Excellence in Inorganic Chemistry, April 2022UAB Chemistry Dept, Award for Innovation in Undergraduate Chemistry Instruction, April 2021