Gerald Grass

Background

About Gerald Grass

Gerald W. Grass, MD - Founder & Medical Director | Ketamine Research Institute Pioneering Precision Medicine in Ketamine Therapy Dr. Gerald W. Grass is an internationally recognized leader in ketamine-based therapy with over 35 years of clinical care experience. As founder of the Ketamine Research Institute, he has revolutionized the field through the development of the RESTORE Ultra-Rapid Infusion Program—a breakthrough protocol that is 2-4 times more effective and up to 6 times longer-lasting than standard ketamine infusions. Academic Foundation Former Assistant Professor of Anesthesiology and Pain Medicine at Yale University School of Medicine, where pioneering ketamine research for depression began in 1994. Previously served as Director of the Yale Pain Medicine Fellowship Program and Chief of Pain Medicine for the Connecticut Veterans Healthcare Administration. Dr. Grass holds extensive training in Anesthesiology, Neurosurgery, Emergency Medicine, and Integrative Medicine, enabling a unique, multidisciplinary approach to ketamine therapy. Unmatched Clinical Experience With more hands-on ketamine infusion experience than any practitioner worldwide, Dr. Grass has personally administered and monitored thousands of sessions over 26+ years. This unprecedented patient-side experience has been instrumental in developing the advanced precision medicine and target-controlled infusion protocols that define modern ketamine therapy. Evidence-Based Innovation Research presented at the American Psychiatric Association, Psych Congress, and governmental agencies demonstrates RESTORE achieves an 88.4% effectiveness rate (versus 18.3-45.5% with standard protocols), with improvements lasting 245 days compared to 26 days with conventional methods. Advancing Professional Standards Established the Ketamine Research Institute "Mini-Fellowship" Training Program—the only U.S. program meeting or exceeding all APA and ASA recommendations. This comprehensive curriculum combines evidence-based didactics, supervised clinical experience, personal experiential training, and year-long mentorship, training clinicians from across North America and internationally. Clinical Specializations Treatment-Resistant Depression & Mood Disorders Anxiety, PTSD & Bipolar Disorder Chronic Neuropathic Pain (Fibromyalgia, CRPS) Emerging neurological applications Dr. Grass continues to advance ketamine therapy through clinical research, innovative treatment development, and comprehensive clinician education—transforming lives through safe, effective, personalized medicine.