Greg Hostetler

Background

About Greg Hostetler

I possess a Master's Degree in organic chemistry with 28 years of industrial experience. As a medicinal chemist for 15 years, my experience included designing and optimizing synthetic routes as well as optimizing SAR and SPR to improve ADME properties and drug-related characteristics such as binding affinity, metabolic stability, CYP binding, hERG liability, and receptor selectivity. Transitioning out of the pharmaceutical industry into the electronics industry, my initial experience in the OLED field involved designing and optimizing the performance of host, dopant, and HTL compounds. My polyimide research involved discovering novel monomers for the development of colorless polyimide films and polymers for the redistribution layer for advanced packaging (FO-WLP). I conducted syntheses of monomers and polymers for the development of low loss waveguides and high refractive index applications. I am a very passionate chemist who delves into the literature to determine past and present research relevant to my efforts to help guide novel idea generation. I'm constantly considering new molecules to synthesize to optimize the performance of the materials our projects focus on. Synthetic experience primarily involves multi-step synthesis of small molecule heterocycles. Extensive experience with palladium-catalyzed reactions (e.g. Buchwald, Suzuki, Heck, Sonogashira, Stille). Proficient in conducting microwave-assisted reactions. Chromatography expertise includes normal phase flash chromatography as well as automated purification using ISCO and reverse-phase preparatory HPLC. Selected List of Lab and Reaction Expertise: Heterocyclic chemistry Palladium catalyzed C-C cross-coupling reactions Palladium-catalyzed aminations Microwave chemistry Air-sensitive techniques (e.g. Schlenk vessels) Column chromatography Solid-phase peptide synthesis (Fmoc protocol) Hydrogenation Recystallization Distillation