James Mathew

Background

About James Mathew

My research for the past 20 years has been in the areas of immune responsiveness and tolerance induction in clinical organ transplantation. These studies have resulted in more than 200 publications including book chapters, review articles and editorials, original papers and presentations. The major thrust of these has been on the immunological effects of donor bone marrow cell (DBMC) and donor hematopoetic stem cell (DHSC) infusions in organ transplant patients using in vitro and ex vivo culture systems. It has been observed that using multiple assays for donor specific unresponsiveness may identify potentially tolerant recipients who may be candidates for immunosuppressive drug (IS) withdrawal. Recent studies have also assessed the role of CD4+CD25High FoxP3+ regulatory T cells as potential tolerance inducers in kidney and liver transplant patients, as well as the differential susceptibility these cells to various immunosuppressive drugs used in clinical transplantation.