Jason Estep

Background

About Jason Estep

I solve the "how do we build this capability" problem that early-stage biotechs face. With 15+ years spanning academic research and industry applications, I specialize in establishing research platforms and regulatory frameworks that enable early discovery programs to move quickly from target identification through preclinical development. My unique combination of hands-on technical expertise, regulatory leadership, and cross-functional training experience allows me to deliver results in resource-constrained environments where speed and compliance are both critical. What I bring to biotechnology teams: PLATFORM DEVELOPMENT: I've built CRISPR screening infrastructure from scratch in 5 months, achieved 100-fold improvements in viral titer production, and designed and implemented in vivo experimental frameworks for target validation studies. I understand both the science and the operational requirements needed to make platforms scalable and robust. REGULATORY LEADERSHIP: I've authored multi-institutional IACUC protocols, developed EH & S safety guidelines, ensured compliance, and contributed to IND-enabling documentation for FDA submissions. Early-stage companies need someone who can navigate regulatory complexity while maintaining scientific rigor. TEAM DEVELOPMENT: I've trained and mentored 16+ researchers across academic and industry settings, developing training programs that ensure knowledge transfer and operational continuity. I'm committed to fostering diverse and inclusive work environments, because the best platforms are only as strong as the people who run them. CROSS-FUNCTIONAL IMPACT: From directing CRO partnerships to managing complex breeding colonies across multiple facilities, I've learned to coordinate resources, timelines, and stakeholders to deliver results that support business objectives. My doctoral work in neurodevelopment resulted in 4 first-author publications and provided the foundation for my expertise in complex genetic systems and advanced in vivo methodologies. My transition to industry at Arc Institute and Terremoto Biosciences has sharpened my focus on translational applications and regulatory compliance. I'm passionate about building the research capabilities that turn promising science into life-changing medicines. Open to connecting with biotechnology leaders, fellow scientists, and anyone working to advance innovative therapeutics. Let's discuss how my platform development, target validation, and regulatory expertise can support your next breakthrough.