Lee Freiburger

Background

About Lee Freiburger

University of British Columbia - Antibody Engineering Consultant - Dec 2024 - current - Provides drug development guidance for the PROGENITER project - Oversees AI/ML team which develops protein engineering computational workflows Gandeeva Therapeutics, Canada Associate Director - Antibody Engineering July 2024 - current - Directed ML scientist to develop internal protein engineering computational workflow - Analyzed biophysical and structural experimental results of engineering proteins Principal Scientist - Program Management May 2022 - Jun 2024 - Oversaw pipeline projects from Target Discovery to Candidate Selection- Key member in target selection committee- Planned, executed and managed work at CROs- Oversaw the set up of the biochemistry lab and trained the protein production team. Zymeworks Inc, Canada Senior Research Scientist – Protein Engineering January 2020 – February 2022 Research Scientist – Protein Engineering May 2016 – January 2020 - Successfully executed over 10 pipeline and platform projects in a crossfunctional team including antibody discovery, bioinformatics, protein engineering, immunology, CMC, and computational chemistry - Oversaw experimental planning for the production and characterization of therapeutic leads within internal labs and third party CROs- Led work to validate several in silico and in vitro assays to predict antibody PK behaviour. Designed and implemented a workflow used for all projects for early stage assessment of lead candidates- Utilized in house in silico tools using structure based design to engineer stability and affinity on a wide variety of molecules: Antibodies, scFvs, ADCs, Bi/tri-specifics, TCRs- Successfully humanized antibodies for internal antibody generation programs. Technische Universitat Munchen – Department of Chemistry, Munich, Germany Postdoctoral Research Fellow October 2011–May 2016 - Marie Curie International Incoming Fellow - EMBO Longterm Fellow - Worked in a collaborative team combining results from structural biology and biochemistry (NMR, electron microscopy, SAXS, AUC) to describe Hsp90 binding interactions with client proteins and cochaperones. PhD Department of Chemistry, McGill University, Montreal, Canada September 2005 – August 2011 Research Topic The Study of Allostery in Aminoglycoside N-6’-Acetyltransferase Through the Use of Calorimetry and Spectroscopy Advisors Prof. Karine Auclair & Prof. Anthony K. Mittermaier - Top PhD thesis in the Department of Chemistry 2011.