Mark Fitzgerald

Background

About Mark Fitzgerald

Creative and strategic project leader and medicinal chemist with expertise from project inception to delivery of development candidates. 5+ years in Targeted Protein Degradation. Skilled in multi-step synthesis and biological data driven analog design. Known for my ability to successfully manage multiple projects and achieve challenging timelines. Effective team leader, collaborator, and communicator, thriving across a range of large team, small team, and independent environments. Experienced in multiple therapeutic areas including oncology, infectious disease, metabolic disease and CNS. Core Competencies: • Hit Finding through Candidate Selection – Experienced from hit finding (DEL, HTS, lit-based, phenotypic and fragment screening) through hit-to-lead and lead optimization. Extensive small molecule and bRo5 molecule experience including heterobifunctionals, macrocycles, covalent inhibitors, peptides and peptidomimetics. • Targeted Protein Degradation – Worked in bifunctional TPD space from finding degrader starting points to delivering development candidates (IV and oral). Designed and synthesized E3 binders (molecular glues), optimizing for substrate degradation selectivity and physicochemical properties. Degraded epigenetic targets, kinases, phosphatases as well as other target classes. • Structure Based Drug Discovery – Routinely use protein structural information for targeting strategy or feasibility assessment as well as for small molecule design and optimization. Experienced using X-Ray crystallography, CryoEM, NMR, HDX and SAXS data in this context.