Maxime Dubail

Background

About Maxime Dubail

I am a radiobiologist passionate about cancer research and innovative therapies that help reduce toxicity to healthy tissues. I received a fellowship grant from JSPS-CNRS, enabling me to pursue research on FLASH radiotherapy. My work involves multi-omics analyses (Lipidomics, Proteomics, and Transcriptomics) on human lung samples irradiated at either ultra-high dose rates or conventional dose rates to better understand the underlying mechanisms of FLASH-RT. This project is funded as part of an international collaboration through INCa AMED - ASPIRE 2024 (France-Japan) between Curie Institute and Hamamatsu University School of Medicine. PhD Project My PhD research focused on identifying molecular biomarkers and cellular targets to predict the response of healthy lung tissue 🫁 to different radiation therapy protocols, including FLASH radiotherapy, using ex vivo/in vivo approaches and single-cell RNA sequencing (scRNA-seq) analysis. Thesis manuscript available here: https://theses.hal.science/tel-04960675 List of Publications ORCID Profile: Recent Oral Communications FRPT21 – New Models for FLASH Studies (Oral) SFBR – Caractérisation de la réponse du poumon sain à la radiothérapie FLASH (Oral) FRPT22 – Studying the FLASH Effect at the Single Cell Level (Oral) ESTRO 2023 – First Evidence of a FLASH Sparing Effect in Human Healthy Lung Samples (Poster) Immunorad 2023 – FLASH Radiotherapy Spares the Transcription of a Lipid Metabolism Pattern Specific to Murine Lung AT2 Cells (Poster) Optimizing Imaging and Dose Response in Radiotherapies Workshop 2023 – Development of an Ex Vivo Assay Enabling Rapid Quantification of Radiotherapy-Induced Toxicities in Healthy Lung (Oral) FRPT23 – First Evidence and Transcriptional Characterization of the FLASH Effect in Human Lung Samples (Oral) FRPT24 – FLASH Radiotherapy Spares Mitochondrial Function in Human Healthy Lung (Oral)