Michael Weiner

Background

About Michael Weiner

Serial Scientific Entrepreneur. Founder and CEO of Abbratech and Precision Biotools. Inventor of site-directed antibodies. Notable life sciences tools developed (all published in scientific peer reviewed literature and most issued US patents) include: 1st to clone and sequence BamHI (Ph.D. thesis, Cornell Univ.), 1st to code the use of a rolling hash computer algorithm for DNA analysis, sole inventor of QuikChange Mutagenesis, pCR-Script directional blunt-ended cloning method, paired-end DNA sequencing, emulsion PCR (454 Life Sciences), droplet PCR (RainDance Technologies), HT Y2H for protein:protein interaction,(GlaxoSmithKline), HT phage display for Ab discovery (Affomix), inventor of DNA bar-coded Luminex beads for multiplex DNA genotyping, expanded radix algorithm for more efficient DNA sequence storage (Illumina), invented the pMINERVA scFv to IgG cloning and expression system (AxioMx). Inventor in NextGen DNA sequencing, and NextGen Proteomics sequencing Founder of Affomix (proteomics, acquired by Illumina), AxioMx (proteomics, acquired by Abcam), GnuBio (NextGen DNA sequencing, acquired by BioRad), and Encodia (NextGen protein sequencing). Director of The Rothberg Institute for Childhood Diseases and CSO of 454 Life Sciences (NextGen DNA Sequencing, Acquired by Roche) and RainDance Technologies (microfluidics, acquired by BioRad). Co-author of papers and named inventor on numerous patents. Editor for BioTechniques and serves on several SABs and BoDs. Member of several NIH review panels and has been awarded over $30M in R01, R21, SBIR Phase I and II, Fast-track, Direct-to Phase II, U19 and U53 grant. Awarded DARPA funding. Winner of both Connecticut Entrepreneur of the year and CiteAb lifetime achievement awards. Ph.D. in Genetics from Cornell University cloning, sequencing and characterizing the psm genes of temperate bacteriophages of Bacillus species, including M.BamHI. Minors in Microbiol. and Biochem. Post-doc designing, synthesizing Thrombin, RNaseA genes, investigated protein refolding under Dr H. Scheraga (Dept of Physical Chemistry, Cornell University). Professional ceramicist, specializing in macro-crystalline glazes and image-transfer onto clay. Invented and submitted several novel methods for image transfer onto clay in Pottery Making Illustrated and has taught several ceramics workshops at Guilford Art Center and Wesleyan Pottery Studio. Scientific specialties: Tech dev: Genetics, Genomics, Mol. Biol, Proteomics, biol. applications in emulsions and small volumes (<50 pL), DNA sequencing, Bioeng, Instrumentation