Mukesh Mudgal

Background

About Mukesh Mudgal

SYNTHETIC ORGANIC CHEMIST Extensive experience in literature search, design, plan, and execution of multi-step organic synthesis of novel compounds, purification, and characterization using instrumental analytical methods to confirm the structures. Expertise in handling instruments like NMR, Mass Spectrometer, HPLC, prep-HPLC, UV, Fluorescence Spectrophotometer, Yamazen purification system, Tangential Flow Filtration, GPC, AKTA protein purification system and Size Exclusion Chromatography (SEC). Proficient in the interpretation of NMR (1H NMR, 13C NMR, and 2D NMRs) and MS and in using research-oriented software like SciFinder, ChemDraw, Endnote, and MestReNova. Experience in handling air and moisture-sensitive reactions using the Schlenk line technique. Gained extensive experience while working in a Medicinal Chemistry department (Drug discovery), Process Development department (Active Pharmaceuticals Ingredients), and in Life Sciences department of companies. CAREER HIGHLIGHTS • Experience in the synthesis of prodrugs (conjugates) by attaching cytotoxic compounds to hydroxyl ethyl starch backbone using non-cytotoxic drug linkers to achieve targeted delivery of anticancer molecules. • Expertise in preparation of antibody-dye conjugates and their purification using Ion Exchange Chromatography and Size Exclusion Chromatography (SEC) employing the AKTA protein purification system. • Extensive experience in the synthesis and purification of hydrophilic PEGylated linkers. • Experience in Medicinal Chemistry – 3.4 years in a company (Oncology)+ 5 years during Ph.D. • Experience in Active Pharmaceutical Ingredients - 2.5 years in the company (Oncology). • Experience in Polymer Chemistry/Small Organic Molecules – 5 years in company. • Involved in the commercialization of a new product at Beckman Coulter - SuperNova v428: New Bright Polymer Dye for Flow Cytometry Applications. • Experience in the synthesis of organic compounds using n-BuLi, Grignard, and Hydride reactions, Radical, Oxidation, Reduction, Coupling, and Pd catalyzed reactions, etc. • An effective trainer capable of building a cohesive teamwork atmosphere, willing to deliver quality results and achieve targets.