Nagakumar Bharatham

Background

About Nagakumar Bharatham

Significant achievements:12+ years of Drug Discovery experience in three start-up companies.1) Initiated and Involved in an anti-bacterial discovery project.current status: Late Phase 12) Initiated and involved in an Immuno-oncology project.current status: Late LO3)Initiated and involving in an oncology project current status: LOComputational Medicinal Chemist with expertise in - Structure-/Ligand-based drug discovery and Drug repurposing by applying the following methods tailored based on the individual project goals and available data• Consensus Pharmacophore based models• Protein-ligand interaction fingerprints for potency and selectivity• Re/Cross docking for ideal pocket selection• Molecular docking and clustering of poses • High throughput Short MD simulations for filtering false positives• Virtual screening for scaffold hopping• Evaluation of known Off-targets• Binding free energy calculations for Protein-ligand complexes• Quantitative structure activity relationships (QSAR)• Development of reliable protein model by Homology modeling in multidisciplinary teams involving biologists, medicinal chemists working towards a common goal.Experience in dealing with Bacterial targets, GPCRs related to IO space, several oncology targets like kinases, bromodomains, PPI targets etc- Contributing to multiple time sensitive projects concurrently as a team member/leader - Communication and written skills verified by active publication and poster presentation recordWork Authorization/permission: UK: Indefinite leave to remain (ILR) India: Citizen