Patrick Augustijns

Background

About Patrick Augustijns

Publications: Patrick Augustijns has a Pharmacy degree, a Master in Medical Sciences and a Ph.D. in Pharmaceutical Sciences. Prior to becoming a professor at the University of Leuven (Belgium), he performed postdoctoral research at the University of Kansas and at GSK (North Carolina). In 2003, Patrick Augustijns became chairman of Drug Delivery and Disposition. The laboratory has a strong track record in the biorelevant profiling of intestinal drug absorption, covering all underlying processes including dissolution, precipitation, degradation and permeation. For this purpose, a wide range of simulation models is available, including the in vitro Caco-2 cell culture system, the Ussing chamber system and the in situ intestinal perfusion system. In addition, Drug Delivery and Disposition is able and licensed to perform whole animal absorption and pharmacokinetic experiments. Physiology-based pharmacokinetic modelling (Simcyp® Simulator - Gastroplus) is available to extrapolate experimental data to human pharmacokinetics. One of the lab’s major research topics involves the bio-relevant and predictive evaluation of absorption-enabling strategies, including solubilization and supersaturation of poorly soluble drugs. In this respect, Drug Delivery and Disposition has elaborated a ground-breaking approach for evaluating intraluminal drug and formulation behavior in humans, which involves the aspiration and in-depth characterization of gastrointestinal fluids. All absorption studies are supported by well-developed analytical equipment (LC-UV-fluo-MS/MS). Patrick Augustijns is (co)author of ± 300 (peer reviewed) papers in international journals and more than 300 presentations at scientific meetings. Since 2008, Patrick Augustijns is AAPS-fellow, an honorary distinction by the American Association of Pharmaceutical Scientists. Specialties: Intestinal absorption - bioanalysis - pharmacokinetics