Rakeshkumar Patel

Background

About Rakeshkumar Patel

Vast experience (more than 13 years) in nonclinical discovery and safety evaluation of NCEs. Conducted more than 20 safety pharmacology studies as a Study Director in IND enabling studies as per OECD principle of GLP. Well verse in murine MCAO model (tMCAO) of stroke, and Behavior assessment for long term outcome post stroke. Good hand in various animal models of neurobehavioral, inflammation, pain and hypertension. In addition to this, I am skillful in various in-vivo/ex-vivo model development and evaluation. Competent in estimation of various biomarkers of inflammation including cytokines estimation. Moreover, I am competent in animal handing (mice, rats, guinea pigs and dogs) for various in-vivo/ex-vivo research. These experiences have strengthened my research and writing skills including careful experimental planning, critical observations, and managing large pool of data for its successful ending. Successfully faced OECD-GLP, and inspections. In-depth knowledge of GLP principles for conducting various regulatory studies. Strong passion for scientific research, career oriented, self-motivated, dedicated, hardworking and I am always excited to embark on a journey to educate myself. Expertise in Drug Discovery Neuropathic pain (CCI and SNL) Inflammatory pain Visceral pain (writhing, Ovariohysterectimy & colorectal distension) Post-operative pain Hot plate and tail flick assay in mice DSS induced colitis in mice LPS induced inflammation Cecal perforation and ligation (CLP) model of sepsis Animals models of poly cystic ovary syndrome Bronchodilatory activity of NCEs using Double chamber plethysmography. CNS: Pentobarbitone induced sleeping time, motor coordination, locomotor activity, Anxiogenic or anxiolytic, antidepressant activity. Irwin test (FOB) and modified Irwin test & Learning and memory test CVS: Blood pressure & ECG of telemetered beagle dogs and anaesthetized guinea pigs (acquisition and analysis) GI: GI transit & gastric ulcer Respiratory: Plethysmography (WBP, HOP & DCP) Cerebral Blood flow measurement in stroke mice Telemetry System for cardiovascular parameters, DSI, Ponemah v 5.00 & EMMS Plethysmography for respiratory parameters, eDacq software 1.9.1 Smart Videotracking system for locomotor activity, Panlab. Smart v 2.5.7 Biopac System