Robert Barrett
Assistant Professor at Cedars-Sinai
Based in Los Angeles, United States
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Seniority
Staff
Department
Healthcare & Human Services
Location
Los Angeles
Industry
Hospitals and Health Care
Company size
16K
Contact information
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r•••••••@cedars-sinai.edu
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Background
About Robert Barrett
The overall research focus of the Barrett Laboratory is to utilize human intestinal organoid technology to learn more about the mechanisms underpinning inflammatory bowel disease (IBD). Our current research focus is on developing a personalized model of intestinal fibrosis, which is a common and potentially serious complication of IBD. This fibrosis model involves directing induced pluripotent stem cells (iPSC), generated from affected IBD patients, to form human intestinal organoids and subsequently determining their responses to cytokines associated with this complication. Small microengineered Chip technology will be used to examine how microbes and cell-cell interactions play a role in this process. Other areas of interest involve determining how inflammatory cytokines influence the functioning and permeability of intestinal epithelial cells and also characterizing iPSC-derived and biopsy-derived human intestinal organoids. Specialties: Induced pluripotent stem cell culture, human intestinal organoid culture, small microengineered Chip technology, 3-dimensional tissue culture, immunocytochemistry, flow cytometry, molecular biology, brightfield, fluorescent and confocal microscopy.
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