Ryan Olsen

Background

About Ryan Olsen

I am a Ph.D. Cell and Molecular Biologist dedicated to de-risking complex oligonucleotide and small molecule drug candidates through the preclinical pipeline. As a Study Director, I specialize in translating high-throughput bench data into the rigorous, submission-ready reports required for IND-enabling filings.My Ph.D. was a unique immersion, serving as the sole biologist within a Medicinal Chemistry laboratory. My depth of understanding enables me to bridge departmental gaps and drive cross-functional collaboration. I understand the underlying physicochemical drivers that impact assay performance and drug development.Core Competencies:DMPK/ADME, In Vitro DDI, Induction, Transporters, Permeability, Metabolic Stability.Regulatory Leadership: I lead ICH M12-compliant studies from protocol design through final reporting, ensuring strict adherence to FDA/ICH guidelines for global sponsors.Specialized Modalities: Extensive experience managing in vitro assays for DNA/RNA (Oligonucleotides) and small molecules.Cross-Functional Liaison: I thrive at the interface of external sponsors and internal bioanalytical teams, optimizing study designs to ensure "right-the-first-time" data delivery.Operational: Study Direction, GLP/Regulatory Compliance, Protocol-to-Report Management.Analytical: Bioanalytical Data Interpretation and Oversight, Radioactivity/LSC, Microplate Readers, HPLC, ELISA/LFIA.Data Science: Python, R, GraphPad Prism, SoftMax Pro, Excel.