Stefano Comai

Background

About Stefano Comai

Acquired skills and techniques: • Stereotaxic neurosurgery in rats and mice. • In-vivo Electroencephalographic and Electromyographic (EEG/EMG) recordings and analysis in rodents. • In-vivo electrophysiology of serotonin, norepinephrine, dopamine, hippocampal and cortical neurons. • Behavioural pharmacology. Animal paradigms of anxiety and depression: Elevated plus Maze, Novelty Suppressed Feeding, Open Field, Forced Swim, Sucrose Preference, and Light/Dark Box tests. • Drug discovery process. • Translational approach: from bench to bedside. • Enzymatic and antimicrobial assays. • Chromatographic techniques: HPLC with UV and fluorometric detectors. • Mass spectrometry. • Study of biomarkers of diseases. • Extraction and characterization of pharmaceutical compounds from medicinal plants. S. Comai, G. Gobbi. Unveiling the role of melatonin MT2 receptors in sleep, anxiety and other neuropsychiatric diseases: a novel target in psychopharmacology. J Psychiatry Neurosci. S. Comai, et al. Sleep-wake cycle in Melatonin MT1, MT2 and MT1/MT2 receptor knockout mice. Behav Brain Res 2013;243:231-8. S. Comai, et al. The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 2: atypical antipsychotics, anticonvulsants and lithium. J Clin Psychopharmacol 2012, 32:237-60. S. Comai, et al. The Psychopharmacology of Aggressive Behavior: A Translational Approach. Part 1: Neurobiology. J Clin Psychopharmacol 32, 83-94, 2012. R. Ochoa-Sanchez#, S. Comai#, et al. MT2 melatonin receptor ligands promote NREM sleep: involvement of reticular thalamic neurons. J Neurosci, 31, 18439-18452, 2011.# equal contribution. S. Comai, et al. Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C. Pharmacol Res, 63, 85-92, 2011. S. Comai, et al. Serum Levels of Tryptophan, 5-Hydroxytryprophan and Serotonin in Patients Affected with Different Forms of Amenorrhea. IJTR, 3, 69-75, 2010.