Subhadwip Basu

Background

About Subhadwip Basu

I am a dedicated and proactive synthetic and analytical medicinal chemist with 8 years of extensive experience in designing, synthesizing, purifying, and characterizing diverse drug-like small molecules. My expertise spans creative drug design, medicinal chemistry strategies, innovative synthetic chemistry, structure-activity relationship (SAR), and computational modeling analyses. With a solid understanding of pharmacokinetics (PK) and pharmacodynamics, I excel in optimizing physicochemical properties for pharmaceutical development, with 5 years dedicated to lead optimization. Key Highlights • Innovative Drug Discovery: Successfully identified a highly potent preclinical candidate as a small molecule immunomodulator against PD-L1 through a comprehensive drug discovery R&D endeavor. • Lead Optimization Expert: Led campaigns that significantly improved the solubility and permeability of inhibitors, resulting in compounds with wider therapeutic indexes. • Cutting-Edge Research: Developed novel fluorescent probes and TR-FRET competitive binding assays, enhancing the precision of PD-L1 inhibitor differentiation. • Analytical Mastery: Expert in developing and optimizing HPLC/UPLC/LC-MS/LC-MS-MS bioanalytical methods for plasma drug concentration measurement, aiding in the planning of animal efficacy studies. I am passionate about leveraging my skills and experience to contribute to impactful drug discovery projects. I am also deeply interested in the application of AI and machine learning principles to computer-aided drug discovery, aiming to enhance the efficiency and accuracy of drug design processes. I welcome opportunities to connect with fellow professionals, industry experts, and organizations interested in medicinal chemistry, process development, and pharmaceutical innovation. Together, we can explore innovative solutions to advance transformative therapies and significantly improve patients' lives.