Thomas Rossetti

Background

About Thomas Rossetti

In 2017, I graduated from Brandeis University with a B.S in Biology and Chemistry. My undergraduate research with Dr. John Lisman focused on the CaMKII protein and its involvement in learning and memory processes in the hippocampus. From the Fall of 2017 to the Winter of 2023, I was a student in the Pharmacology Ph.D. program at the Weill Cornell Graduate School of Medical Sciences. I conducted my Ph.D. work in the Levin/Buck laboratory. My work in the lab focused on developing and characterizing inhibitors of soluble adenylyl cyclase (sAC), with the goal of generating a "drug-like" sAC inhibitor that could be used for various therapeutic applications. In pursuit of this goal, I developed several improved sAC-focused assays for assessing the efficacy defining features of our small molecule inhibitors (with a specific focus on studying inhibitor binding kinetics). As a postdoctoral associate in the Levin/Buck lab, I am currently part of a team that are using the insights gained from our previous studies to develop sAC inhibitors with enhanced therapeutic properties. Additionally, I am leading efforts in the lab to identify novel, tissue-specific isoforms of sAC. If successful, our findings could lead to the development of tissue-selective sAC inhibitors, which would limit any potential off-target side effects. I am always interested in discussing collaborations and future opportunities!