Xiaomin Yu

Background

About Xiaomin Yu

RESEARCH INTERESTS Next generation sequencing data analysis and data mining, whole genome/exome sequencing, RNA-seq and ChIP-seq data analysis Identify disease causal genes by whole genome/exome sequencing Genome-wide association study of common/complex diseases RNA-seq for transcriptome analysis and small RNA analysis Population genetic analysis of SNPs Comparative and Functional genomics analysisPROFESSIONAL EXPERIENCEApr. 2015-present Research Fellow NIAID Clinical Genomics Program National Institute of Allergy and Infectious Disease, National Institutes of Health Whole genome sequencing for large cohort of genetic diseases associated with atopy (co-operate with Merck Research Laboratories and Broad Institute). Using whole exome sequencing to identify disease causal genes in diseases associated with atopy. Using exome-sequencing-SNP-based linkage analysis to identify susceptibility loci in elevated serum tryptase associated with atopy and connective tissue abnormalities.May.2012-Apr.2015 Postdoctoral Visiting Fellow National Institute of Allergy and Infectious Disease, National Institutes of Health T-cell receptor repertoires analysis using deep-sequencing in human syndromes of immunodeficiency Identified gain-of-function mutations in a gene causing allergic rhinitis and asthma in a specific Jewish population. Identified loss-of-function mutations in PGM3 causing a recessively inherited atopy, immune deficiency, autoimmunity, and neurocognitive impairment.Jun.2010-Apr.2012 Postdoctoral Visiting Fellow National Cancer Institute, National Institutes of Health RNA-seq analysis of nautilus (MyoD) null and wild-type Drosophila.