Renoir Itn

RENOIR: REcreating the ideal Niche: environmental control Of cell Identity in Regenerating and diseased muscles. RENOIR is a four year, European Training Network granted by the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement No 860034. RENOIR aims to develop and implement an integrated structural PhD training programme for 13 Early Stage Researchers (ESRs) in the field of muscle regeneration and aging. The major objective of RENOIR research programme is to ultimately unravel, using novel and integrated biotechnological tools, the progressive decline in skeletal and cardiac muscle mass and functionality, that represents the most critical and complex features associated with human ageing and disease. MAIN OBJECTIVES- Molecular determinant of the identity of satellite cells We investigate how the different stem and progenitor cells in the muscle acquire and maintain their fate using genetic lineage tracing strategies in transgenic mice and loss/gain of function models- Environmental control of muscle homeostasis, regeneration and aging We focus on how the inflammatory, myogenic and vascular components integrate to coordinate muscle regeneration and how fibrosis develops in pathological conditions - Biomaterials and biological drugs-assisted regeneration We engineer novel biomaterials and devices to reconstruct the extra-cellular matrix and the muscle niche in vitro that can recapitulate the role of the biochemical signals in muscle regeneration CONSORTIUM RENOIR is a European Training Network that brings together 9 academic and 6 non-academic participants. 13 Beneficiaries 2 Partner Organisations