Ashish Sonkar
Senior Research Investigator at Syngene International Limited
Based in Bengaluru, India
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Seniority
Staff
Department
Science
Location
Bengaluru
Industry
Pharmaceutical Manufacturing
Company size
7.8K
Contact information
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a•••••••@syngeneintl.com
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Background
About Ashish Sonkar
Pharmacokinetic/Toxicokinetic studies: In-vivo pharmacokinetics/toxicokinetics (bioavailability, excretion, tissue distribution, and dose proportionality studies) of xenobiotics in preclinical animals using the different routes of administration (Oral, I.V, S.C, etc.). Bio-analysis: Method development and validation for xenobiotics quantification in different matrices (e.g. blood, plasma, urine, tissues, and water, etc.) using UPLC, LC-MS/MS. In-vitro metabolism: Metabolic stability, CYP450/UGTs phenotyping & inhibition studies of xenobiotics using recombinant enzymes/microsomes/S9 fraction as a test system. Human pharmacokinetics prediction: In-vitro in-vivo extrapolation (IVIVE) using in-vitro and in-vivo preclinical data for predicting the pharmacokinetics/toxicokinetics in humans. Risk assessment: Integration of species difference in metabolism & toxicokinetics, and PBPK modeling for assessing the risk of environmental toxicants/toxins exposure on human health.
Decision-makers
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Saravanan Balu
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Anish Rajput
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- MMManager
Manish Mohan
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